The Adrien Albert Laboratory

of Medicinal Chemistry

Department of Pharmacology, The University of Sydney,

Sydney, NSW, 2006, Australia

Last updated 14 December 1999

Specialised facilities available to staff and students of the Adrien Albert Laboratory of Medicinal Chemistry, Department of Pharmacology, The University of Sydney

Behavioural Pharmacology

Two purpose built rooms and equipment to study in mice the effects of new chemical entities on anxiety (elevated plus maze) and memory (Morris water maze).

Computational Chemistry and Molecular modelling

IBM and Silicon Graphics workstations running AMPAC, AMSOL, Catalyst, Gaussian 94, Molpro, and MOPAC for the computer aided design of new chemical entities. Macintosh and Pentium computers running Chem-X, Chem 3D, Macromodel and Spartan. Access to supercomputing (Silicon Graphics Power Challenge) at the NSW Centre for Parallel Computing.

Molecular Biology

Facilities for PCR, site-directed mutagenesis and preparation of chimeric cloned receptors and transporters. Access to sequencing via the The Sydney University Prince Alfred Macromolecular Analysis Centre (SUPAMAC).

Neurochemistry

Facilities for the study of neurotransmitter binding, uptake and release in preparations of nervous tissue. The laboratory has access to human postmortem brain issue through the NISAD Centre for Collaborative Human Brain Research at the University of Sydney.

Neuropharmacology

Equipment for the study of drug action on tissue slice preparations (cortical wedges, hippocampal slices), and on cloned receptors and transporters expressed in Xenopus oocytes.

Organic Chemistry

Two well equipped laboratories for preparative organic chemistry.

Spectroscopy

Varian Gemini 300 MHz NMR spectrometer.
Hewlett Packard HP5890 gas chromatograph/mass spectrometer.

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