The Laboratory's research is directed towards the development of drugs selectively active at multiple excitatory amino acid and GABA receptor sites and transporters, and to drugs acting on ATP-gated potassium channels using structure-activity studies and computer-assisted modelling. New chemical entities synthesised in the Adrien Albert Laboratory are evaluated in house on a variety of test preparations.
Structure-activity models of the above receptors suggest new compounds to be investigated as neuroactive substances possibly as agonists, antagonists or modulators at these receptors. Much of the work involves development of routes for the chemical synthesis of these target molecules. One of the important features of this work is that the new compounds are designed, synthesised and tested in isolated tissue preparations and whole animal models within the research group.
Current major research projects include:
Contact: Dr Robin Allan, phone 02 9351 3433, fax 02 9351 3868, e-mail r_allan@pharmacol.usyd.edu.au
Contact: Dr Jan Hanrahan, phone 02 9351 2078, fax 02 9351 4391, e-mail janeh@pharm.usyd.edu.au
Contact: Dr Mary Collins, phone 02 9351 8584, fax 02 9351 4391, e-mail mcollins@pharm.usyd.edu.au
Contact: Professor Graham Johnston, phone 02 9351 6117, fax 02 9351 3868, e-mail grahamj@mail.usyd.edu.au
Contact: Professor Graham Johnston, phone 02 9351 6117, fax 02 9351 3868, e-mail grahamj@mail.usyd.edu.au
Contact: Dr Rujee Duke, phone 02 9351 6204, fax 02 9351 3868, e-mail rujeek@pharmacol.usyd.edu.au
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