Journal of the Society of Chemical Industry, 1945, 64 (June), 169-172.
The reaction whereby 5-chloroacridine is converted into 5-aminoacridine in an open vessel with the aid of phenol and ammonium carbonate (Part 1) has been applied to twenty-four variously substituted 5-chloroacridines, many of which have proved to be powerful antibacterials. The reactions of 5-chloroacridine with ethanolamine and with ethylenediamine are also described.
The University, Sydney
Received April 18, 1945
The historic synthesis of tacrine, now used to treat Alzheimer's Disease - Table 1, compound 29 - 1:2:3:4-Tetrahydro-5-aminoacridine (Modern nomenclature names this compound as 1,2,3,4-Tetrahydro-9-aminoacridine).