About
Professor David Harris-
Professor David Harris is a research leader in the field of progressive chronic kidney disease, internationally recognized especially for his contributions to understanding the role of tubulointerstitial injury in progressive disease.
Novel therapies for treating progressive chronic kidney disease
Summary
The use of DNA vaccination and regulatory cells to treat progressive kidney disease.
Supervisor(s)
Research Location
Westmead Millennium Institute, Centre for Transplantation and Renal Research
Program Type
PHD
Synopsis
This project is examining the use of regulatory lymphocytes, regulatory macrophages and regulatory dendritic cells as treatments for progressive kidney disease. Regulatory phenotype is achieved by in vitro transduction of regulatory genes, or by application of cytokines which determine the regulatory phenotype. DNA vaccination using genes identified to be important players in the progression of kidney disease will also be used as a novel approach to therapy. The effect on treatment efficacy of vaccination against multiple genes will be examined. These novel therapies are being examined in rodent models of diabetic and non-diabetic kidney disease. It is anticipated that this research will ultimately lead to the definition therapies to be applied to human kidney disease.
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Keywords
Progressive chronic kidney disease, Regulatory cells, DNA vaccination, Chronic diseases & ageing, Therapeutics & adverse drug effects, Human body, Pharmacology & therapeutics
Opportunity ID
The opportunity ID for this research opportunity is: 201