About
Dr Stuart Cordwell-
Our group is primarily interested in utilizing the tools of proteomics to understand disease processes and discover new targets for protein-based diagnosis of disease and potential vaccine and therapeutic targets.
Post-translational modifications in bacterial proteins
Summary
This project will identify novel proteins that are post-translationally modified in bacterial pathogens and the role of such modification in virulence.
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Synopsis
Post-translational modifications, such as phosphorylation and glycosylation, modify the structure and function of proteins. Furthermore, protein cleavage provides antigenic variation and may dictate novel functions. This project will examine both global protein modifications (e.g. phosphoproteomics) as well as characterize modifications in individual proteins such as the CadF adhesin of Campylobacter jejuni. Oxidative stress, caused by the release of toxic reactive oxygen species (ROS) from inflammatory immune cells, must be overcome by the majority of human pathogens. This project aims to identify how oxidative stress modifies protein expression, as well as determine whether disulfide bond formation is induced under such conditions.
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Keywords
Cystic fibrosis, Gastrointestinal Disease, Guillain-Barre Syndrome, Antibiotic resistance, Proteomics, Phosphorylation, Glycosylation, oxidative stress, mass spectrometry, Infectious diseases, Cell biology, Infection & immunity
Opportunity ID
The opportunity ID for this research opportunity is: 65
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