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Research Students
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Claire Deakin
Gene therapy for X-linked severe combined immunodeficiency (SCID-X1)
While two clinical trials of SCID-X1 gene therapy have shown success, some infants developed leukaemia as a result of the integrating virus used for gene delivery, a risk previously estimated as insignificant. My PhD project at the Children’s Medical Research Institute is focussed on developing an alternative, safer gene delivery system. My project also includes an ethics component to investigate risk and uncertainty in clinical gene therapy, which allows me to draw on my undergraduate training in science and law.
Sanket Joshi
Dynamin II as a potential anti-cancer drug target
My PhD project is to determine if the cellular protein dynamin II (dynII) is a potential anti-cancer drug target. DynII is implicated in the last step of the cell division process, called cytokinesis. Cell division is tightly regulated so that cells only divide when necessary and any damaged cells are killed. Cancer develops when this control is lost. We hope to stop the proliferation of cancer cells by targeting dynamin. This may result in stabilization or regression of a tumour. My research is conducted at the Children’s Medical Research Institute, part of the Westmead Research Hub.
Natalie D'Abrew
Impact of breast and gynaecological cancer in terms of the male partner's experience
I'm looking at the experience of male partners whose female partner is diagnosed with breast or gynaecological cancer. My research focuses on the impact of this disease in relation to body image and sexuality from the male partner's perspective. The aim is to improve knowledge of how male partners cope and to explore possible interventions for the male partner during this time.
Kat Leaver
Neuroprotection and Parkinson's Disease
Currently the most effective treatments available to treat PD only alleviate the symptoms. There is a need to develop neuroprotective drugs which slow or stop the progression of the disease. Early intervention may help slow the onset of debilitating symptoms. I'm doing a cotutelle PhD, and so will be completing a year of research in Tours, France. I have the opportunity to travel to present at conferences.
Josh Stern
Recruitment of human telomerase to telomeres
My PhD at Children’s Medical Research Institute aims to understand how cancer cells achieve immortality. The chromosome ends, or telomeres, of normal cells shorten with age. This eventually causes cells to stop dividing. In cancer cells this does not happen. Most of the time this is because the telomerase enzyme repeatedly extends the telomeres. My goal is to work out what key factors recruit telomerase to the telomeres allowing it to extend the chromosomes.
Elucidating the neurobiological underpinnings of mania and depression in patients with bipolar disorder using simultaneous fMRI-EEG.
TheDepartment of Psychological Medicine at Royal North Shore Hospital undertakesneuroimaging research into cognitive functioning and underlying brain processesin neuropsychiatric disorders. more...
Supervisor(s):
Lagopoulos, Jim (Associate Professor)
Research Location:
Psychological Medicine, Royal North Shore Hospital
Program Type:
PHD
Keywords:
fMRI, EEG, neuroimaging, brain, bipolar disorder, Psychiatry, mania, depression, biomedical engineering
Genes, Environment and Brain Function in Well-Being
The key goal of this project is to identify genetic, environmental and brain markers of well-being in healthy individuals and twins. more...
Supervisor(s):
Williams, Lea (Professor), Gatt, Justine (Dr)
Research Location:
The Brain Dynamics Centre, Westmead Millennium Institute
Program Type:
Keywords:
Well-being, emotional stability, mental disorders, depression, anxiety, stress, Neuroscience, Cognitive neuroscience, Brain imaging, MRI, Electrophysiology, EEG, cognition, Emotion, Genetics, behaviour, psychiatric disorders, Neuroscience & psychology, gene-environment, twins, health, health psychology, heritability
Elucidating the mechanisms of action of transcranial direct current stimulation
The Department of Psychological Medicine at Royal North Shore Hospital undertakes neuroimaging research into cognitive functioning and underlying brain processes in neuropsychiatric disorders. more...
Supervisor(s):
Lagopoulos, Jim (Associate Professor)
Research Location:
Psychological Medicine, Royal North Shore Hospital
Program Type:
PHD
Keywords:
direct current stimulation, brain, fMRI, EEG, depression, Neuroscience, bipolar disorder, neuroimaging
Cricket and golf biomechanics
This project is a cluster of available studies on sports biomechanics with partucular emphasis on cricket and golf: Segment velocity contribution in cricket bowling Power flow analysis of injury susceptible bowling actions Three-dimensional kinematics and lower lumbar kinetics analysis of the golf swing Upper body kinetics analysis of the golf swing Biomechanics analysis of cricket batting drives Biomechanics analysis of cricket throwing and baseball pitchingEEG, attention and golf putting mechanics EEG and focussing strategies of elite cricket batters Kinematics and kinetics analysis of kicking in soccer, rugby and AFL footballKinematics and kinetics analysis of tennis serve, forehand and backhand strokes . more...
Supervisor(s):
Research Location:
Exercise, Health and Performance Faculty Research Group, Faculty of Health Sciences
Program Type:
Keywords:
Back injury, spondylolysis, spondylolisthesis, shoulder counter-rotation, crunch factor, anxiety, sport psychology, yips, Biomechanics, kinematics, kinetics, power cricket, batting, bowling, fielding, throwing mechanics, golf, driving, putting, electroencephalography, EEG, technique, Movement disorders, Health & lifestyle, Human body, Movement, fast bowling, spin bowling, swing bowling, kicking, rugby, soccer, side-kick, instep kick, tennis, serve, forehand, backhand
Sleep Health - This project is a group of studies investigating how the various factors of exercise, food and beverages may affect sleep health in normal individuals, athletes or those with sleep complaints.
The cluster of projects employs skills in polysomnography (sleep EEG, EMG and ECG).. more...
Supervisor(s):
Research Location:
Exercise, Health and Performance Faculty Research Group, Faculty of Health Sciences
Program Type:
Keywords:
Sleep, diet, exercise training, sports performance, sleep deprivation, insomnia, adolescents
Clinical Psychology Interventions and Translational Neuroscience
To improve cognitive-behavioural interventions and develop a better understanding of the interaction between biological and psychological processes. more...
Supervisor(s):
Research Location:
Brain and Mind Research Institute
Program Type:
Masters/PHD
Keywords:
Oxytocin, D-Cycloserine, anxiety, autism, substance misuse, cognitive-behaviour therapy, emotion-processing, youth mental health, interventon, community mental health, Neuroscience, DCS
Sleep and Circadian Dynamics
This research area is concerned with developing quantitative, physiologically-based, mathematical models of the diurnal, circadian, and ultradian processes that govern sleep dynamics, and in applying the results to design and interpret experiments and clinical studies.. more...
Supervisor(s):
Research Location:
Program Type:
Masters/PHD
Keywords:
physics, biological physics, biomathematics, Neuroscience, brain dynamics, sleep research, sleep medicine, circadian rhythms, diurnal rhythms, Biophysics, nonlinear dynamics
Brain Dynamics
This research area aims to develop and apply quantitative physiologically-based models of brain activity that span multiple scales from microscopic to the whole brain, and of how this activity relates to underlying stimuli and processing on one hand, and to measurements on the other. more...
Supervisor(s):
Research Location:
Program Type:
Masters/PHD
Keywords:
physics, biological physics, biomedical physics, Medical physics, biomathematics, Neuroscience, brain dynamics, Biophysics, nonlinear dynamics, networks, neural networks, neuronal networks, brain structure, brain connectivity, brain mapping, functional connectivity, Applied mathematics, computational neuroscience, neurophysiology, neuroanatomy, electroencephalography, Brain imaging, fMRI, Electrophysiology, seizures, epilepsy, Parkinson’s Disease, complex systems, theoretical physics, computational physics
Visual Development and Dynamics
This research area will apply and test quantitative physiologically-based models of the development and response properties of primary visual cortex, to better understand how visual features are detected and bound into unified percepts.. more...
Supervisor(s):
Research Location:
Program Type:
Masters/PHD
Keywords:
physics, biological physics, biomedical physics, Medical physics, biomathematics, Neuroscience, brain dynamics, Biophysics, nonlinear dynamics, networks, neural networks, neuronal networks, brain structure, brain connectivity, brain mapping, functional connectivity, Applied mathematics, computational neuroscience, neurophysiology, neuroanatomy, electroencephalography, Electrophysiology, gamma oscillations, Vision, primary visual cortex, Development, perception, self-organization, complex systems, theoretical physics
Neurobiological investigations of substance use and psychosis.
Despite the understanding that methamphetamine use increases the risk for and exacerbates psychosis, few studies have investigated the underlying neurobiology. more...
Supervisor(s):
Hickie, Ian (Professor), Hermens, Daniel (Dr)
Research Location:
Brain and Mind Research Institute
Program Type:
Masters/PHD
Keywords:
neurobiology, neuropsychology, neurophysiology, Psychosis, methamphetamine, cannabis, schizophrenia.